GSK143
Product Specifications
CAS Number
1240390-27-5
Target
Others, ERK, Syk
Related Pathways
MAPK, Others, Angiogenesis, Tyrosine Kinase/Adaptors
Bioactivity
GSK143 is a potent orally active and highly selective inhibitor of spleen tyrosine kinase (SYK) with a pIC 50 of 7.5. Furthermore, GSK143 effectively inhibits phosphorylated Erk (pErk) with a pIC 50 value of 7.1. In addition, GSK143 exhibits promising anti-inflammatory properties by reducing inflammation and impeding the recruitment of immune cells in the intestinal muscularis of mice.
Smiles
Cc1ccc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)ncc2C(N)=O)cc1
Molecular Formula
C17H22N6O2
Molecular Weight
342.403
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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