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GSK143

Product Specifications

CAS Number

1240390-27-5

Target

Others|||ERK|||Syk

Related Pathways

MAPK|||Others|||Angiogenesis|||Tyrosine Kinase/Adaptors

Bioactivity

GSK143 is a potent orally active and highly selective inhibitor of spleen tyrosine kinase (SYK) with a pIC 50 of 7.5. Furthermore, GSK143 effectively inhibits phosphorylated Erk (pErk) with a pIC 50 value of 7.1. In addition, GSK143 exhibits promising anti-inflammatory properties by reducing inflammation and impeding the recruitment of immune cells in the intestinal muscularis of mice.

Smiles

Cc1ccc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)ncc2C(N)=O)cc1

Molecular Formula

C17H22N6O2

Molecular Weight

342.403

Shipping Conditions

Cool pack

Storage Temperature

-20°C

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