Prexasertib dimesylate
Product Specifications
CAS Number
1234015-58-7
Target
Apoptosis, Chk, Others
Related Pathways
Apoptosis, Others, Cell Cycle/Checkpoint
Bioactivity
Prexasertib dimesylate (LY2606368 dimesylate) is a highly selective, ATP-competitive, second-generation inhibitor of checkpoint kinase 1 (CHK1), with a K_i of 0.9 nM and an IC_50 of <1 nM, and also effectively inhibits CHK2 (IC_50 = 8 nM) and RSK1 (IC_50 = 9 nM) . Its mechanism induces double-stranded DNA breakage and replication catastrophe, leading to apoptosis, and demonstrates potent anti-tumor activity.
Smiles
CS(O)(=O)=O.CS(O)(=O)=O.COc1cccc(OCCCN)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Molecular Formula
C20H27N7O8S2
Molecular Weight
557.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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