Ac-hMCH (6-16) -NH2

Product Specifications

CAS Number

1053601-50-5

Target

Melanin-concentrating Hormone Receptor (MCHR) |||GPCR

Related Pathways

Endocrinology/Hormones|||GPCR/G Protein

Bioactivity

Ac-hMCH (6-16) -NH2 shows non-selective agonist activity towards both MCH-1R and MCH-2R, which are human MCH receptors in the brain. The compound effectively binds to and activates these receptors, with IC 50 values of 0.16 nM and 2.7 nM for MCH-1R and MCH-2R, respectively.

Smiles

CSCC[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(N)=O|@:53|