ROC-0929
Product Specifications
CAS Number
1048660-43-0
Target
Others|||Phospholipase
Related Pathways
Others|||Metabolism
Bioactivity
ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A2 (sPLA2s), targeting hGX with an IC50 of 80 nM. It efficiently inhibits the phosphorylation of ERK1/2 and p-38. sPLA2s, part of the disulfide-rich, Ca2+-dependent enzyme family, catalyze the hydrolysis of glycero-phospholipids at the sn-2 position, releasing a fatty acid and a lysophospholipid. ROC-0929 is promising for research on inflammation-related diseases.
Smiles
CC(C)Cc1c(C(=O)C(N)=O)c2c(OC(C)C(=O)NS(=O)(=O)c3ccccc3)cccc2n1Cc1ccccc1
Molecular Formula
C30H31N3O6S
Molecular Weight
561.65
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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