Manzamine A hydrochloride
Product Specifications
CAS Number
104264-80-4
Target
Others, Proton pump, Parasite, HSV, GSK-3, Autophagy, CDK
Related Pathways
Microbiology/Virology, Cell Cycle/Checkpoint, Others, PI3K/Akt/mTOR signaling, Autophagy, Stem Cells, Membrane transporter/Ion channel
Bioactivity
Manzamine A hydrochloride is an orally active beta-carboline alkaloid that exhibits specific inhibitory effects on GSK-3β (IC50 = 10.2 μM) and CDK-5 (IC50 = 1.5 μM) . Additionally, it targets vacuolar ATPases, leading to the inhibition of autophagy in pancreatic cancer cells. Manzamine A hydrochloride possesses antimalarial and anticancer properties, and also demonstrates potent activity against HSV-1[4].
Smiles
Cl.[H][C@]12C[C@]34CN5CC[C@@]3([H])C(=C[C@@](O)(CC\C=C/CCCC5)[C@]4([H])N1CCCC\C=C/2)c1nccc2c3ccccc3[nH]c12
Molecular Formula
C36H45ClN4O
Molecular Weight
585.23
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
More Discoveries
Explore Other Products
Browse additional items from our catalog
LH05058V 100 µg
C3orf84 (NM_001080528) Human Over-expression Lysate
Sign In for Pricing
View Details GTR15261571 1 Vial
Lentiviral mouse Rsl1d1 shRNA (UAS) - Lentiviral mouse Rsl1d1 shRNA (UAS) plasmid
Sign In for Pricing
View Details ARP72237_P050 100 µL
GOLGA6L1 Antibody - middle region (ARP72237_P050)
Sign In for Pricing
View Details DZ06456-Dylight594 200 µL
Anti-Zebrafish PXDN Antibody, Dylight594 Conjugate
Sign In for Pricing
View Details