Manzamine A hydrochloride
Product Specifications
CAS Number
104264-80-4
Target
Others|||Proton pump|||Parasite|||HSV|||GSK-3|||Autophagy|||CDK
Related Pathways
Microbiology/Virology|||Cell Cycle/Checkpoint|||Others|||PI3K/Akt/mTOR signaling|||Autophagy|||Stem Cells|||Membrane transporter/Ion channel
Bioactivity
Manzamine A hydrochloride is an orally active beta-carboline alkaloid that exhibits specific inhibitory effects on GSK-3? (IC50 = 10.2 ?M) and CDK-5 (IC50 = 1.5 ?M) . Additionally, it targets vacuolar ATPases, leading to the inhibition of autophagy in pancreatic cancer cells. Manzamine A hydrochloride possesses antimalarial and anticancer properties, and also demonstrates potent activity against HSV-1[4].
Smiles
Cl.[H][C@]12C[C@]34CN5CC[C@@]3([H])C(=C[C@@](O)(CC\C=C/CCCC5)[C@]4([H])N1CCCC\C=C/2)c1nccc2c3ccccc3[nH]c12
Molecular Formula
C36H45ClN4O
Molecular Weight
585.23
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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