Lariatin A

Lariatin A is an antimycobacterial lasso peptide originally isolated from R. jostii. It is active against M. tuberculosis and M. smegmatis in vitro (MICs = 0.39 and 0.1 μg/ml, respectively) . Lariatin A increases survival in a silkworm model of M. smegmatis infection (ED50 = 0.5 μg/g) .

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