R-8507
Product Specifications
CAS Number
338773-13-0
Target
I?B/IKK|||Others|||Interleukin|||TNF|||RIP kinase
Related Pathways
Apoptosis|||Immunology/Inflammation|||Others|||NF-?B
Bioactivity
R-8507 is a small molecule antagonist of the TNF-? type 1 receptor (TNF-?RI) . It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-? and IL-1? with EC50 values of 2.45 and 3.79 ?M, respectively, in an ELISA using A549 lung epithelial cells. It also disrupts the interaction of the TNF-?RI with receptor interacting protein 1 (RIP1) and TNF-?R-associated death domain protein (TRADD), preventing internalization of the receptor complex.
Smiles
FC(F)(F)C1=NC2=CC=CC=C2N2C(=NN=C12)C1=CC=C(Cl)C=C1
Molecular Formula
C16H8ClF3N4
Molecular Weight
348.71
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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