CU-76
Product Specifications
CAS Number
2400954-58-5
Target
CGAS|||Others
Related Pathways
Immunology/Inflammation|||Others
Bioactivity
CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS; IC50= 0.24 ?M) .1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. CU-76 decreases IFN-stimulatory DNA-induced production of IFN-? in THP-1 cells when used at concentrations of 10, 30, and 100 ?M.
Smiles
N(C=1N=C(C(OC)=O)N=C(N)N1)C2=CC(F)=C(I)C(F)=C2
Molecular Formula
C11H8F2IN5O2
Molecular Weight
407.11
Shipping Conditions
Cool pack
Storage Temperature
-20°C
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6408616-01 0.1 mL
BLVRB (Biliverdin reductase B, FLR, BVRB, SDR43U1, HEL-S-10) (MaxLight 490)
Sign In for Pricing
View Details MBS6408616-02 5x 0.1 mL
BLVRB (Biliverdin reductase B, FLR, BVRB, SDR43U1, HEL-S-10) (MaxLight 490)
Sign In for Pricing
View Details 
MBS6180515-01 0.1 mL
ATOX1 (ATX1 Antioxidant Protein 1 Homolog (yeast), ATX1, HAH1, MGC138453, MGC138455) (HRP)
Sign In for Pricing
View Details MBS6180515-02 5x 0.1 mL
ATOX1 (ATX1 Antioxidant Protein 1 Homolog (yeast), ATX1, HAH1, MGC138453, MGC138455) (HRP)
Sign In for Pricing
View Details