C2-8
Product Specifications
CAS Number
300670-16-0
Target
Huntingtin|||Others
Related Pathways
Neuroscience|||Others
Bioactivity
C2-8 is an inhibitor of polyglutamine (polyQ) aggregation with IC50s of 25 and 0.05 ?M for recombinant HDQ51 and in PC12 cells, respectively. It also limits polyQ aggregation in organotypic hippocampal slice cultures from R6/2 transgenic mice and reduces neurodegeneration dose-dependently in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) decreases huntingtin aggregate size, reduces neuronal atrophy, and enhances motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington's disease.
Smiles
BrC1=CC=C(NC(=O)C2=CC(=CC=C2)S(=O)(=O)NC2=CC=C(Br)C=C2)C=C1
Molecular Formula
C19H14Br2N2O3S
Molecular Weight
510.2
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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