Benzomalvin C
Product Specifications
CAS Number
157047-98-8
Target
Others, Neurokinin receptor
Related Pathways
Neuroscience, GPCR/G Protein, Others
Bioactivity
Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor, inhibiting binding of substance P by 46% at 100 μg/ml in vitro, and a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC50 value of 130 μM for recombinant IDO. Isolated from Penicillium, it contains an epoxide group at C-19 and C-20, absent in benzomalvins A, B, or E.
Smiles
CN1C(=O)c2ccccc2-n2c(nc3ccccc3c2=O)C11OC1c1ccccc1
Molecular Formula
C24H17N3O3
Molecular Weight
395.418
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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