Nirogacestat dihydrobromide
Product Specifications
CAS Number
1962925-29-6
Target
Apoptosis|||Gamma-secretase|||Others
Related Pathways
Apoptosis|||Proteases/Proteasome|||Others|||Neuroscience|||Stem Cells
Bioactivity
Potent ?-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively) . Reduces A? in brain, CSF and plasma in mice and guinea pigs.
Smiles
Br.Br.CCC[C@H](N[C@H]1CCc2cc(F)cc(F)c2C1)C(=O)Nc1cn(cn1)C(C)(C)CNCC(C)(C)C
Molecular Formula
C27H43Br2F2N5O
Molecular Weight
651.48
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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