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TBK1/IKKε-IN-4

Product Specifications

CAS Number

1381930-17-1

Target

Others, IκB/IKK

Related Pathways

Others, NF-κB

Bioactivity

TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nM, respectively. This compound exhibits significantly reduced activity, by 100- to 1000-fold, against other protein kinases, such as PDK1, PI3K family members, and mTOR[1].

Smiles

COc1ccc(cc1)-n1ncc2cnc(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)nc12

Molecular Formula

C28H35N7O4

Molecular Weight

533.62

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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