TBK1/IKKε-IN-4
Product Specifications
CAS Number
1381930-17-1
Target
Others, IκB/IKK
Related Pathways
Others, NF-κB
Bioactivity
TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nM, respectively. This compound exhibits significantly reduced activity, by 100- to 1000-fold, against other protein kinases, such as PDK1, PI3K family members, and mTOR[1].
Smiles
COc1ccc(cc1)-n1ncc2cnc(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)nc12
Molecular Formula
C28H35N7O4
Molecular Weight
533.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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