Noraramtide
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC) . This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity[1].
Product Specifications
CAS Number
2580150-96-3
Product Name Alternative
BHV-1100
UNSPSC
12352209
Target
CD38
Type
Peptides
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/noraramtide.html
Smiles
CCCCC[C@H]1C(N[C@@H](CC2=CC=C(O)C=C2)C(N[C@@H](CC3=CN=CN3)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC4=CC=C(C5=CC=CC=C5)C=C4)C(N[C@@H](CCCCC)C(N[C@@H](CC(O)=O)C(N[C@H](C(NCCOCCOCCOCCOCCOCCOCCN6C7=C(N=N6)CC[C@H]8[C@@H](CC7)[C@H]8COC(N9CCC(C(NCC(N[C@H](C(O)=O)CCC(N[C@@H](C(O)=O)CCC(N[C@@H](C(N[C@@H](C(O)=O)CCC(N[C@@H](C(O)=O)CCC(NCC(NCC(N[C@H](C(N[C@H]%10CSSC[C@@H](C(N[C@H](C(O)=O)[C@H](O)C)=O)NC([C@H](CC%11=CNC%12=CC=CC=C%12%11)NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC(CNC([C@H](CC(C)C)NC([C@H](CC%13=CNC=N%13)NC([C@H](CC%14=CNC%15=CC=CC=C%15%14)NC([C@H](C)NC%10=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)CCC(O)=O)=O)=O)=O)=O)CC9)=O)=O)CSCC(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N1)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C210H300N48O65S3
Molecular Weight
4633.11
References & Citations
[1]Birch G C, et al. Expansion, persistence, and characteristics of autologous, Bhv-1100 armored memory-like NK cells infused prior to autologous stem cell transplant in MRD+ multiple myeloma patients: a first-in-human trial[J]. Blood, 2023, 142: 2105.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
Phase 1
Frequently Asked Questions
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