STING Agonist 12b
Product Specifications
CAS Number
2411100-70-2
Target
Others|||STING
Related Pathways
Immunology/Inflammation|||Others
Bioactivity
STING agonist 12b is an agonist of stimulator of interferon genes (STING) .1It binds to STING (Kd= 26.4 ?M) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 ?M, respectively) . STING agonist 12b (40 ?M) induces expression of TNF-a, IL-6, IP-10, and IL-1b in THP-1 cells.
Smiles
O=C1C=2C(NC=3C1=CC=C(C)C3C)=CC=C(OC)C2
Molecular Formula
C16H15NO2
Molecular Weight
253.3
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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