JJH260
Product Specifications
CAS Number
1831135-30-8
Target
Others, MAGL, Androgen Receptor
Related Pathways
Others, Metabolism, Endocrinology/Hormones
Bioactivity
JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs) . It blocks the hydrolysis of 9-PAHSA with an IC50 value of 0.57 μM. JJH260 also inhibits the novel FAHFA hydrolase androgen-dependent TFPI-regulating protein (ADTRP; IC50 = 8.5 μM), as well as the serine hydrolase ABHD6 and the lysophospholipases LYPLA1 and LYPLA2. JJH260 inhibits the FAHFA hydrolase activity of LNCaP and T cell lysates and intact cells.
Smiles
O=C1C2N(C(=O)N1OC(=O)N3CCC(CCC4=CC=C(Cl)C=C4)CC3)CCN(C(=O)C5=CC=C(N(C)C)C=C5)C2
Molecular Formula
C29H34ClN5O5
Molecular Weight
568.06
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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