Reveromycin B
Product Specifications
CAS Number
144860-68-4
Target
Others, Antibacterial
Related Pathways
Microbiology/Virology, Others
Bioactivity
Reveromycin B is a spiroketal bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells (IC50 = 6 μg/ml) and exhibits pH-dependent antifungal activity against C. albicans [MICs = 15.6 and >500 μg/ml at pH 3.0 and 7.4, respectively]. Unlike reveromycin A and reveromycin C, reveromycin B does not inhibit the proliferation of KB and K562 cells.
Smiles
CCCC[C@@]1(CC[C@]2(CC[C@H](C)[C@@H](C\C=C(/C)\C=C\[C@H](O)[C@@H](C)\C=C\C(O)=O)O2)O1)[C@@H](OC(=O)CCC(O)=O)\C=C\C(\C)=C\C(O)=O
Molecular Formula
C36H52O11
Molecular Weight
660.79
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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