Fumonisin B1

Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin[1][2].

Product Specifications

CAS Number

[116355-83-0]

UNSPSC

12352211

Hazard Statement

H301, H351, H361, H373

Target

Acyltransferase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/fumonisin-b1.html

Purity

99.96

Solubility

H2O : 16.67 mg/mL (ultrasonic)

Smiles

OC(C[C@@H](C(O)=O)CC(O[C@@H](C[C@@H](C)C[C@H](O)CCCC[C@@H](O)C[C@H](O)[C@@H](N)C)[C@@H]([C@H](C)CCCC)OC(C[C@H](C(O)=O)CC(O)=O)=O)=O)=O

Molecular Formula

C34H59NO15

Molecular Weight

721.83

Precautions

H301, H351, H361, H373

References & Citations

[1]Henry MH, et al. The toxicity of fumonisin B1, B2, and B3, individually and in combination, in chicken embryos. Poult Sci. 2001 Apr;80 (4) :401-7.|[2]Shephard GS, et al. Disruption of sphingolipid metabolism in non-human primates consuming diets of fumonisin-containing Fusarium moniliforme culture material. Toxicon. 1996 May;34 (5) :527-34.|[3]Wang SK, et al. Effect of fumonisin B₁ on the cell cycle of normal human liver cells. Mol Med Rep. 2013 Jun;7 (6) :1970-6.