LEO 39652
Product Specifications
CAS Number
1445656-91-6
Target
Others, PDE
Related Pathways
Metabolism, Others
Bioactivity
LEO 39652, a dual-soft PDE4 inhibitor, demonstrates potent inhibition of PDE4 subtypes A, B, C, and D with respective IC50 values of 1.2 nM, 1.2 nM, 3.0 nM, and 3.8 nM. Additionally, it inhibits TNF-α with an IC50 of 6.0 nM, indicating its potential for topical Atopic dermatitis (AD) research [1].
Smiles
COc1ccc(-c2ccc3C(=O)OCc3c2)n2nc(nc12)C1(CC1)C(=O)OCC(C)C
Molecular Formula
C23H23N3O5
Molecular Weight
421.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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