(S) -Coriolic acid
Product Specifications
CAS Number
29623-28-7
Target
PPAR, Mitochondrial Metabolism, Lipoxygenase
Related Pathways
Metabolism, DNA Damage/DNA Repair
Purity
0.9804
Bioactivity
(S) -Coriolic acid (13 (S) -HODE) is an important intracellular signaling agent generated by the reaction of linoleic acid with plant and mammalian lipoxygenases. It is involved in cell proliferation and differentiation in various biological systems and inhibits the adhesion of tumor cells to the vascular endothelium, while down-regulating IRGpIIb/IIIa receptor expression at around 1 μM. Additionally, (S) -Coriolic acid is a metabolite of 15-lipoxygenase (15-LOX) and often acts as an endogenous ligand to activate PPARγ. It induces mitochondrial dysfunction and airway epithelial damage.
Smiles
C(=C/C=C\CCCCCCCC(O)=O)\[C@H](CCCCC)O
Molecular Formula
C18H32O3
Molecular Weight
296.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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