12 (S) -HEPE
Product Specifications
CAS Number
116180-17-7
Target
Lipoxygenase, Others, Leukotriene Receptor
Related Pathways
Metabolism, GPCR/G Protein, Others
Bioactivity
12 (S) -HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12 (S) -HEPE to 12 (S),20-diHEPE, while stimulated neutrophils produce 5 (S),12 (S) -HEPE via the 5-lipoxygenase pathway. The competitive action of 12 (S) -HEPE with arachidonic acid as a substrate for 5-LO in leukotriene formation may underlie the anti-inflammatory potential of ω-3 fatty acids.
Smiles
C(\[C@H](C/C=C\C/C=C\CC)O)=C/C=C\C/C=C\CCCC(O)=O
Molecular Formula
C20H30O3
Molecular Weight
318.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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