5-hydroxy Diclofenac
Product Specifications
CAS Number
69002-84-2
Target
Others, Apoptosis, Drug Metabolite
Related Pathways
Metabolism, Apoptosis, Others
Bioactivity
5-hydroxy Diclofenac is a metabolite of the NSAID diclofenac formed by the cytochrome P450 (CYP) isoform CYP3A4. Diclofenac is a non-selective COX inhibitor. It inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 μM, respectively. Diclofenac inhibits ovine COX-1 and -2 with IC50 values of 60 and 220 nM, respectively.
Smiles
OC(=O)Cc1cc(O)ccc1Nc1c(Cl)cccc1Cl
Molecular Formula
C14H11Cl2NO3
Molecular Weight
312.15
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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