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AP 14145 hydrochloride

Product Specifications

Target

Others

Related Pathways

Others

Bioactivity

KCa2 (small conductance Ca2+-activated potassium) channel negative allosteric modulator (IC50 = 1.1 μM) . Increases the EC50 of Ca2+ on KCa2.3 channels by ~3-fold. Prolongs atrial effective refractory period (AERP) in rats. Reduces atrial fibrillation (AF) duration and prolongs atrial refractoriness without affecting ventricular refractory period in an animal AF model.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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