AP 14145 hydrochloride
Product Specifications
Target
Others
Related Pathways
Others
Bioactivity
KCa2 (small conductance Ca2+-activated potassium) channel negative allosteric modulator (IC50 = 1.1 ?M) . Increases the EC50 of Ca2+ on KCa2.3 channels by ~3-fold. Prolongs atrial effective refractory period (AERP) in rats. Reduces atrial fibrillation (AF) duration and prolongs atrial refractoriness without affecting ventricular refractory period in an animal AF model.
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/C3E624E2-F5D3-4358-950E-1564A6E285C1/T37821
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