Streptazolin

Streptazolin is a fungal metabolite originally isolated from S. viridochromogenes. It increases NF-?B activity when used at concentrations ranging from 60 to 130 ?g/ml, at least in part, via PI3K signaling. Streptazolin enhances TNF-? secretion induced by LPS and enhances IL-8 secretion when used alone or in combination with LPS in THP-1 Blue cells.