CAY10608
Product Specifications
CAS Number
457897-92-6
Target
Others|||Potassium Channel|||iGluR
Related Pathways
Others|||Membrane transporter/Ion channel|||Neuroscience
Bioactivity
N-Methyl-D-aspartate (NMDA) receptors are Ca2+ permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. CAY10608 is a propanolamine that potently, selectively, and non-competitively antagonizes the NR2B subunit of NMDA receptors (IC50 = 50 nM) . It does not inhibit NR1, NR2A, NR2C, and NR2D subunits and has no significant effects on ?-amino-3-hydroxy-5-methyl-4-isoxazolepropioinic acid (AMPA) or kainate receptors. CAY10608 is neuroprotective, since it prevents NMDA-triggered release of lactate dehydrogenase from cultured cortical neurons. Also, CAY10608, when administered intraperitoneally, reduces brain infarct volume resulting from transient ischemia via carotid artery occlusion.
Smiles
N(S(C)(=O)=O)C1=CC=C(OC[C@H](CNCCC2=CC(Cl)=C(Cl)C=C2)O)C=C1
Molecular Formula
C18H22Cl2N2O4S
Molecular Weight
433.35
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/E4E3CCA8-41FA-46FE-A161-A0D21F101149/T37671
Available Sizes
Curated Selection
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