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Polygalacic acid

Product Specifications

CAS Number

22338-71-2

Target

AChR|||MMP|||Cholinesterase (ChE)

Related Pathways

Neuroscience|||Proteases/Proteasome

Purity

0.9982

Bioactivity

Polygalacic acid (Virgaureagenin G) is a triterpenoid isolated from the root of Polygala tenuifolia Willd that inhibits MMP expression. Polygalacic acid (Virgaureagenin G) can significantly improve the responsiveness of the cholinergic system, such as decreased acetylcholinesterase (AChE) activity, increased choline acetyltransferase (ChAT) activity, and increased acetylcholine (ACh) levels in the hippocampus and frontal cortex. Polygalacic acid (Virgaureagenin G) can also inhibit IL-1?-induced Wnt/?-catenin activation and mitogen-activated protein kinase (MAPK) signaling pathways in chondrocytes, and is used in osteoarthritis (OA) related research.

Smiles

CC1(C)CC[C@@]2([C@H](O)C[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]34C)[C@H]2C1)C(O)=O

Molecular Formula

C30H48O6

Molecular Weight

504.7

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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