LY 2886721 Hydrochloride

Potent and selective ?-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively) . Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits A?1-40 and A?1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical A? and sAPP? levels in an Alzheimer's disease mouse model.