LY 2886721 Hydrochloride
Product Specifications
CAS Number
1262036-49-6
Target
Others|||Beta-Secretase
Related Pathways
Neuroscience|||Others
Bioactivity
Potent and selective ?-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively) . Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits A?1-40 and A?1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical A? and sAPP? levels in an Alzheimer's disease mouse model.
Smiles
Cl.[H][C@@]12COC[C@@]1(N=C(N)SC2)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Molecular Formula
C18H17ClF2N4O2S
Molecular Weight
426.87
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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