ITK inhibitor

Interleukin-2-inducible T cell kinase (ITK) is a non-receptor tyrosine kinase expressed in T cells, NKT cells and mast cells which plays a crucial role in regulating the T cell receptor (TCR), CD28, CD2, chemokine receptor CXCR4, and FcepsilonR-mediated signaling pathways. ITK inhibitors can be used for the treatment of inflammation and immune-mediated disorders. ITK inhibitor (N-[5-[[3-[ (4-Acetylpiperazin-1-yl) carbonyl]-4-methyl-6-methoxy-phenyl]thio]thiazol-2-yl]-4- (N-1,2-dimethylpropylaminomethyl) benzamide) is the analogue of BMS-509744, which can potently and selectively inhibit Itk kinase activity.