DMHAPC-Chol
Product Specifications
CAS Number
794494-38-5
Target
Others
Related Pathways
Others
Bioactivity
DMHAPC-Chol is a cationic cholesterol. Liposomes containing DMHAPC-chol have been used for DNA plasmid delivery in vitro and in vivo in a B16-F10 mouse xenograft model. Liposomes containing DMHAPC-chol are cytotoxic to B16-F10 cells when used at lipid concentrations greater than 20 ?M. DMHAPC-Chol, as part of a lipoplex with DOPE , has also been used to deliver DNA into mouse lung via intratracheal injection, resulting in a heterogeneous distribution in the bronchi and bronchioles, and to deliver VEGF siRNA into A431 and MDA-MB-231 cells, which secrete VEGF.
Smiles
C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CCCC(C)C)C)(CC4)[H])[H])(CC=C1C[C@@H](OC(NCCC[N+](CCO)(C)C)=O)CC2)[H])[H]
Molecular Formula
C35H63N2O3
Molecular Weight
559.89
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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