Necrostatin-5
Product Specifications
CAS Number
337349-54-9
Target
Necroptosis, RIP kinase
Related Pathways
Apoptosis, NF-κB
Purity
0.994
Bioactivity
Necrostatin-5 (Nec-5) is a selective RIP1 kinase inhibitor and cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with TNF-α, with an EC50 of 240 nM.
Smiles
O=C1C=2C3=C(SC2N=C(SCC#N)N1C4=CC=C(OC)C=C4)CCCC3
Molecular Formula
C19H17N3O2S2
Molecular Weight
383.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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