Carbazomycin A

Carbazomycin A is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities.1,2It is active againstS. aureus, T. asteroides, andT. mentagrophytes (MIC = 12.5 ?g/ml for all), as well as the plant pathogenic fungusP. oryzae (MIC = 25 ?g/ml) . Carbazomycin A is cytotoxic to MCF-7, KB, NCI H187, and Vero cells (IC50s = 26.2, 30.1, 18.4, and 32.6 ?g/ml, respectively) .2