DOPAL
Product Specifications
CAS Number
5707-55-1
Target
Endogenous Metabolite, Others, Reactive Oxygen Species
Related Pathways
Metabolism, Immunology/Inflammation, NF-κB, Others
Bioactivity
DOPAL is an aldehyde product of the oxidative deamination of dopamine by monoamine oxidase.[1] It can be further oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH) and, to a lesser extent reduced to 3,4-dihydroxyphenyl ethanol (DOPET) . DOPAL is toxic to neurons.[2], [3] It can also oligomerize and precipitate α-synuclein, an event associated with Parkinson's disease.[2] Mice lacking cytosolic and mitochondrial forms of ALDH display increased levels of DOPAL as well as neurodegeneration and motor dysfunction characteristic of Parkinson's disease.[4]
Smiles
O=CCC1=CC=C(O)C(O)=C1
Molecular Formula
C8H8O3
Molecular Weight
152.15
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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