MSNBA

MSNBA is a potent and selective GLUT5 fructose transport inhibitor with an IC50 of 0.10 mM. MSNBA does not affect the transport activity of human GLUT1, GLUT2, GLUT3, GLUT4 or bacterial GlcPSe. MSNBA competitively inhibits GLUT5 fructose uptake with a Ki of 3.2 μM in MCF7 cells. MSNBA can be used for the study of cancer or diabetes[1].

Product Specifications

CAS Number

[852702-51-3]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

GLUT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/msnba.html

Purity

96.86

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=[N+](C1=CC(S(=O)(C)=O)=CC=C1NC2=CC3=C(OCO3)C=C2)[O-]

Molecular Formula

C14H12N2O6S

Molecular Weight

336.32

Precautions

H315, H319, H335

References & Citations

[1]George Thompson AM, et al. Discovery of a specific inhibitor of human GLUT5 by virtual screening and in vitro transport evaluation. Sci Rep. 2016 Apr 14;6:24240.|[2]Włodarczyk J, et al. Blockade of fructose transporter protein GLUT5 inhibits proliferation of colon cancer cells: proof of concept for a new class of anti-tumor therapeutics. Pharmacol Rep. 2021 Jun;73 (3) :939-945.