Ac-PAL-AMC
Product Specifications
CAS Number
1431362-79-6
Target
Others, Proteasome
Related Pathways
Others, Ubiquitination, Proteases/Proteasome
Bioactivity
Ac-PAL-AMC is a fluorogenic substrate for the β1i/LMP2 subunit of the 20S immunoproteasome. Upon cleavage, 7-amino-4-methylcoumarin (AMC) is released, and its fluorescence can quantify the activity of the β1i/LMP2 subunit. Ac-PAL-AMC is selective for the immunoproteasome over the constitutive proteasome. AMC displays excitation/emission maxima of 351/430 nm.
Smiles
CC=1C=2C(=CC(NC([C@@H](NC([C@@H](NC(=O)[C@H]3N(C(C)=O)CCC3)C)=O)CC(C)C)=O)=CC2)OC(=O)C1
Molecular Formula
C26H34N4O6
Molecular Weight
498.57
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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