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Ac-PAL-AMC

Product Specifications

CAS Number

1431362-79-6

Target

Others|||Proteasome

Related Pathways

Others|||Ubiquitination|||Proteases/Proteasome

Bioactivity

Ac-PAL-AMC is a fluorogenic substrate for the ?1i/LMP2 subunit of the 20S immunoproteasome. Upon cleavage, 7-amino-4-methylcoumarin (AMC) is released, and its fluorescence can quantify the activity of the ?1i/LMP2 subunit. Ac-PAL-AMC is selective for the immunoproteasome over the constitutive proteasome. AMC displays excitation/emission maxima of 351/430 nm.

Smiles

CC=1C=2C(=CC(NC([C@@H](NC([C@@H](NC(=O)[C@H]3N(C(C)=O)CCC3)C)=O)CC(C)C)=O)=CC2)OC(=O)C1

Molecular Formula

C26H34N4O6

Molecular Weight

498.57

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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