Afizagabar
Product Specifications
CAS Number
1398496-82-6
Target
GABA Receptor, Others
Related Pathways
Membrane transporter/Ion channel, Others, Neuroscience
Bioactivity
Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the α5-GABAAR, with an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. It enhances hippocampal synaptic plasticity and exhibits pro-cognitive efficacy [1].
Smiles
CC1=NN=C(c2cc3c(F)cccc3s2)c2cc3oc(=O)[nH]c3cc2C1
Molecular Formula
C19H12FN3O2S
Molecular Weight
365.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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