Amyloid-? (1-8, A2V) Peptide

Amyloid-? (1-8, A2V) is a truncated form of amyloid-? (A?) that contains a valine to alanine substitution at position 2 of the A? numbering convention (A? A2V), which corresponds to position 673 of the amyloid precursor protein (APP) numbering convention (APP A673V) . An A? (1-40) (A?40) A2V peptide increases the production of A? and the rate and amount of amyloid fibril formation in vitro, effects that can be reduced by coincubation with wild-type A?40. A?40 and A?42 levels are increased in CHO cells expressing the A? A2V mutation and in fibroblasts derived from patients with the A? A2V mutation. As a homozygous mutation, A? A2V is correlated with Alzheimer's disease with distinctive pathological features, but disease does not develop in patients with a heterozygous A? A2V mutation.