PROTAC IDO1 Degrader-1
Product Specifications
CAS Number
2488851-89-2
Target
Indoleamine 2,3-Dioxygenase (IDO), PROTACs, IDO
Related Pathways
PROTAC, Metabolism
Bioactivity
PROTAC IDO1 Degrader-1, a pioneering compound, efficiently targets indoleamine 2,3-dioxygenase 1 (IDO1) for ubiquitination and degradation by recruiting IDO1 to the CRBN E3 ligase, thereby facilitating its entry into the ubiquitin-proteasome system (UPS) with a DC50 of 2.84 μM. This compound also moderately enhances the tumor-killing efficacy of HER2 CAR-T cells[1].
Smiles
O\N=C(/Nc1ccc(F)c(Br)c1)c1nonc1NCCNCCOCCOCCOCCOCCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
Molecular Formula
C40H53BrFN9O13
Molecular Weight
966.816
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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