JKE-1674
Product Specifications
CAS Number
2421119-60-8
Target
GPX, Glutathione Peroxidase, Ferroptosis
Related Pathways
Metabolism, Oxidation-Reduction, Apoptosis
Purity
0.9872
Bioactivity
JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and the active metabolite of ML-210, which is converted to butyronitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in the same manner as ML-210 and is completely rescued by ferroptosis inhibitors.
Smiles
O\N=C(/C[N+]([O-])=O)C(=O)N1CCN(CC1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Molecular Formula
C20H20Cl2N4O4
Molecular Weight
451.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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