JKE-1674
Product Specifications
CAS Number
2421119-60-8
Target
GPX, Glutathione Peroxidase, Ferroptosis
Related Pathways
Metabolism, Oxidation-Reduction, Apoptosis
Purity
0.9872
Bioactivity
JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and the active metabolite of ML-210, which is converted to butyronitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in the same manner as ML-210 and is completely rescued by ferroptosis inhibitors.
Smiles
O\N=C(/C[N+]([O-])=O)C(=O)N1CCN(CC1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Molecular Formula
C20H20Cl2N4O4
Molecular Weight
451.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LV624932 1.0 µg DNA
SRSF11 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA)
Sign In for Pricing
View Details 
039473-AP 200 µL
OR6N2, CT (OR6N2, Olfactory receptor 6N2, Olfactory receptor OR1-23) (AP) discontinued
Sign In for Pricing
View Details 