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JKE-1674

Product Specifications

CAS Number

2421119-60-8

Target

GPX|||Glutathione Peroxidase|||Ferroptosis

Related Pathways

Metabolism|||Oxidation-Reduction|||Apoptosis

Purity

0.9872

Bioactivity

JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and the active metabolite of ML-210, which is converted to butyronitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in the same manner as ML-210 and is completely rescued by ferroptosis inhibitors.

Smiles

O\N=C(/C[N+]([O-])=O)C(=O)N1CCN(CC1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1

Molecular Formula

C20H20Cl2N4O4

Molecular Weight

451.3

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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