M62812
Product Specifications
CAS Number
613263-00-6
Target
TLR
Related Pathways
Immunology/Inflammation
Purity
0.9907
Bioactivity
TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL) . Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic shock model.
Smiles
Cl.Cl.NC1=NSC2=C1C=CC(OC1=C(N)C=CC=C1)=C2
Molecular Formula
C13H13Cl2N3OS
Molecular Weight
330.23
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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