15 (R) -Lipoxin A4

Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function. 15 (R) -Lipoxin A4 (15 (R) -LXA4) is derived from the aspirin-triggered formation of 15 (R) -HETE from arachidonic acid. [1] [2] 15 (R) -LXA4 inhibits LTB4-induced chemotaxis, adherence, and transmigration of neutrophils with twice the potency of LXA4 demonstrating activity in the nM range.[2] [3] The anti-inflammatory effects of aspirin may be ascribed in part to the ability of 15 (R) -LXA4 to regulate leukocyte function.[4] 15 (R) -LXA4 is reported to promote resolution of inflammation in LPS-treated stromal cells derived from intermediate-stage diseased supraspinatus tendons as evidenced by increased expression of the STAT-6 pathway target genes, ALOX15 and CD206.[5]