Azamulin
Product Specifications
CAS Number
76530-44-4
Target
Cytochromes P450
Related Pathways
Metabolism
Bioactivity
Azamulin is a selective, irreversible inhibitor of cytochrome P450 (CYP) 3A isoforms (IC50 values range from 26 to 240 nM for CYP3A4 and CYP3A4/5 from different sources) . [1] It is at least 50-fold less potent against CYP2J2 and 100-fold less effective against all other CYP isoforms. [1] Azamulin potently blocks the hydroxylation of testosterone and midazolam by CYP3A4.[2]
Smiles
[H][C@@]12C(=O)CC[C@]11CC[C@@H](C)[C@@]2(C)[C@@H](C[C@@](C)(CC)[C@@H](O)[C@@H]1C)OC(=O)CSc1nnc(N)[nH]1
Molecular Formula
C24H38N4O4S
Molecular Weight
478.65
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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