Mivebresib
Product Specifications
CAS Number
1445993-26-9
Target
Apoptosis, Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic, Apoptosis
Purity
0.9932
Bioactivity
Mivebresib (ABBV-075), also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD) -containing protein) with potential antineoplastic activity. Upon administration, the bromodomain inhibitor ABBV-075 binds to the acetyl-lysine binding site in the BRD of certain BRD-containing protein (s), thereby preventing the interaction between those proteins and acetylated histones. This disrupts chromatin remodeling, prevents the expression of certain growth-promoting genes, and leads to an inhibition of cell growth in susceptible tumors. Also a potent inhibitor of MYC and the TMPRSS2-ETS fusion proteins.
Smiles
O(C1=C(C=2C3=C(C(=O)N(C)C2)NC=C3)C=C(NS(CC)(=O)=O)C=C1)C4=C(F)C=C(F)C=C4
Molecular Formula
C22H19F2N3O4S
Molecular Weight
459.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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