YNT-185 dihydrochloride
Product Specifications
CAS Number
1804978-82-2
Target
Others, OX Receptor
Related Pathways
GPCR/G Protein, Others, Neuroscience
Bioactivity
Potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells) . Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells) . Depolarizes OX2-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice.
Smiles
Cl.Cl.COc1ccc(cc1S(=O)(=O)Nc1cccc(NCCNC(=O)c2ccccc2N(C)C)c1)-c1cccc(c1)C(=O)N(C)C
Molecular Formula
C33H39Cl2N5O5S
Molecular Weight
688.67
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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