(Z) -4EGI-1
Product Specifications
CAS Number
901787-88-0
Target
Others, PERK
Related Pathways
Apoptosis, Others
Bioactivity
(Z) -4EGI-1, the Z-isomer of 4EGI-1, serves as an inhibitor of both the eIF4E/eIF4G interaction and translation initiation. It effectively binds to eIF4E, exhibiting an IC50 of 43.5 μM and a Kd value of 8.74 μM. Notably, (Z) -4EGI-1 possesses anticancer activity[1][2].
Smiles
N(/N=C(/CC1=C(N(=O)=O)C=CC=C1)\C(O)=O)C2=NC(=CS2)C3=CC(Cl)=C(Cl)C=C3
Molecular Formula
C18H12Cl2N4O4S
Molecular Weight
451.28
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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